Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1
نویسندگان
چکیده
منابع مشابه
Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium.
PURPOSE The existence of an organic cation transport process in rabbit cornea and conjunctiva that mediates absorption of carnitine has previously been suggested. This study was conducted to determine the expression and localization of the carnitine/organic cation transporter (OCTN1 and OCTN2) in corneal or conjunctival epithelium. METHODS Reverse transcriptase-polymerase chain reaction (RT-P...
متن کاملFunctional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.
Carnitine/organic cation transporter (OCTN1/SLC22A4) accepts various therapeutic agents as substrates in vitro and is expressed ubiquitously, although its function in most organs has not yet been examined. The purpose of the present study was to evaluate functional expression of OCTN1 in small intestine and liver, using octn1 gene knockout [octn1(-/-)] mice. After oral administration of [(3)H]e...
متن کاملFunctional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).
It has been reported that organic cation/carnitine transporter 1 (OCTN1) is associated with rheumatoid arthritis and Crohn's disease. Additionally, we reported that OCTN1 is expressed in hematopoietic cells, and is associated with proliferation and differentiation of erythroid cells. However, physiological role of OCTN1 is still unclear. Ergothioneine, an anti-oxidant, was recently reported to ...
متن کاملFunctional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: possible involvement in neuronal differentiation.
The aim of the present study is to clarify the functional expression and physiological role in brain neurons of carnitine/organic cation transporter OCTN1/SLC22A4, which accepts the naturally occurring antioxidant ergothioneine (ERGO) as a substrate in vivo. After intracerebroventricular administration, the distribution of [(3)H]ERGO in several brain regions of octn1(-/-) mice was much lower th...
متن کاملlangauge needs analysis of undergraduate business management and economics students
the aim of conducting this study was to investigate the foreign language learning needs of undergraduate economics students and business management students in faculties of social sciences of alzahra and azad naragh university. in the study, which was designed on the basis of a qualitative-quantitative basis using interviews and questionnaires, 146 female undergraduate business management as we...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2010
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-010-0076-z